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STEM CELL RESEARCH

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STEM CELL RESEARCH

see "DISCOVERY" for related links


There is, in fact, no reason to believe that any given natural
phenomenon, however marvelous it may seem today, will
remain forever inexplicable. Soon or late the laws governing
the production of life itself will be discovered in the laboratory,
and man may set up business as a creator on his own account.
The thing, indeed, is not only conceivable; it is even highly
probable.
--H.L. (Henry Louis) Mencken (1880—1956)
American journalist and literary critic.
_Treatise on the Gods_ [1930], ch. 5 "Its State Today"

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Stem cells can be found in adult beings. Adult stem cells reproduce daily
to provide certain specialized cells — for example 200 billion red blood
cells are created each day in the body. Until recently it was thought that
each of these cells could produce just one particular type of cell — this is
called differentiation (see Morphogenesis). However in the past few
years, evidence has been gathered of stem cells that can transform into
several different forms. Bone marrow stem cells are known to be able
to transform into liver, nerve, muscle and kidney cells.

Adult stem cells may be even more versatile than this. Researchers at
the New York University School of Medicine have extracted stem cells
from the bone-marrow of mice which they say are pluripotent. Turning
one type of stem cell into another is called transdifferentiation.

Stem Cells

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The pattern in the media reportage about stem cells is growing very wearisome. When a research advance occurs with embryonic stem cells, the media usually give the story the brass-band treatment. However, when researchers announce even greater success using adult stem cells, the media reportage is generally about as intense and excited as a stifled yawn.

As a consequence, many people in this country continue to believe that embryonic stem cells offer the greatest promise for developing new medical treatments using the body's cells — known as regenerative medicine — while in actuality, adult and alternative sources of stem cells have demonstrated much brighter prospects. This misperception has societal consequences, distorting the political debate over human cloning and embryonic-stem-cell research (ESCR) and perhaps even affecting levels of public and private research funding of embryonic and adult stem-cell therapies.

This media pattern was again in evidence in the reporting of two very important research breakthroughs announced within the last two weeks. Unless you made a point of looking for these stories — as I do in my work — you might have missed them. Patients with Parkinson's disease and multiple sclerosis received significant medical benefit using experimental adult-stem-cell regenerative medical protocols. These are benefits that supporters of embryonic-stem-cell treatments have yet to produce widely in animal experiments. Yet adult stem cells are now beginning to ameliorate suffering in human beings.

Celebrity Parkinson's disease victims such as Michael J. Fox and Michael Kinsley regularly tout ESCR as the best hope for a cure of their disease. Indeed, the Washington Post recently published a Kinsley rant on the subject in which the editor and former Crossfire co-host denounced opponents of human cloning as interfering with his hope for a cure. Yet as loudly as Fox and Kinsley promote ESCR in the media or before legislative committees, both have remained strangely silent about the most remarkable Parkinson's stem-cell experiment yet attempted: one in which researchers treated Parkinson's with the patient's own adult stem cells.

[...]

Stem cells were harvested from the patient's brain using a routine brain biopsy procedure. They were cultured and expanded to several million cells. About 20 percent of these matured into dopamine-secreting neurons. In March 1999, the cells were injected into the patient's brain.

Three months after the procedure, the man's motor skills had improved by 37 percent and there was an increase in dopamine production of 55.6 percent. One year after the procedure, the patient's overall Unified Parkinson's Disease Rating Scale had improved by 83 percent — this at a time when he was not taking any other Parkinson's medication!

--Wesley J. Smith
"Spinning Stem Cells A damning reporting pattern."


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